Our synthetic polymer-lipid nanoparticles mimic functional components of host cell membranes, tricking viruses and parasites into binding to the particles instead of the host cells.

Our puff-ball inspired microrobotic system combines high cargo loading, strong cargo protection, on-demand cargo release and magnetic-guided locomotion towards an exceptional control over drug delivery.

This work showcases the implementation of light-modulated communication processes between artificial cells based on polymer-enzyme ensembles to achieve homeostasis as one of the hallmarks of life. 

CrisprZyme combines CRISPR-Cas and catalytic metallic nanoparticles into an ultra-sensitive and versatile diagnostic platform for the detection of ncRNA.

Semi-synthetic goldilocks material design integrates the tunable characteristics of synthetic materials and the refined complexity of natural components, enabling for the progress of biomaterials across length scales.

Congratulations to Sam for his PhD viva with the thesis "The development of a platform to manipulate cardiomyocyte structure and function".

Our paper investigating the mechanisms behind cargo transfer using porous silicon nanoneedles as minimally invasive drug delivery tools has been published in Advanced Materials. Congratulations to Sahana Gopal for a great first author paper and to the whole team involved!

Stevens Group tissue engineers published a great paper in Advanced Materials on buoyancy-driven gradients for osteochondral applications. The work was also featured in the media. Well done Chunching Li and team!

[Advanced Science News]

Stevens Group members Chris Wood and Michael Thomas, as joint first authors, with collaborators from the i-sense consortium Jobie Budd, Tivani Mashamba-Thompson, Kobus Herbst, Deenan Pillay, Rosanna Peeling, Anne Johnson and Rachel McKendry, have published a review in Nature on how mobile health can be implemented in the field in Africa.
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The Stevens Group’s latest Nature Communications article entitled “Single Particle Automated Raman Trapping Analysis" reports on how Raman spectroscopy can be exploited to analyse nanoparticles on a single particle basis, without the need for labelling steps or sequential imaging steps, using a technique called SPARTATM. Stevens Group members Jelle Penders, Isaac Pence, Conor Horgan, Mads Bergholt, Chris Wood, Adrian Najer, Ulrike Kauscher and Anika Nagelkerke all contributed in a terrific team effort. Well done!
[C&EN highlight] [Imperial news highlight] [Discover magazine highlight] [Nanotechweb highlight]

n the most recent issue of Science, our article entitled “Fractal-like hierarchical organization of bone begins at the nanoscale” is led by former Stevens Group postdoc Dr Natalie Reznikov in collaboration with the group of Prof Roland Kroger at York. This report shows how the fractal organisation of bone was elucidated using state-of-the-art high resolution imaging techniques.
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The Stevens Group has been featured on the Back Cover of the most recent issue of Advanced Materials. The report, entitled “Drug Delivery: Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy”, was led by Dr Gregor Fuhrmann and Drs Rona Chandrawati, Paresh Parmar, Timothy Keane, Sergio Bertazzo and Ms Stephanie Maynard and describes how extracellular vesicles can be incorporated in hydrogels as an advanced enzyme-prodrug therapy.

The Stevens Group has been featured on the Front Cover of the most recent issue of ChemBioChem. The report, entitled “MicroRNA Detection by DNA-Mediated Liposome Fusion”, was led by Stevens group alumnus Dr Coline Jumeaux and also includes Stevens Group member Eunjung Kim and alumni Rona Chandrawati and Philip Howes, in collaboration with Prof Fredrik Höök and describes how liposome fusion can be mediated by DNA to selectively detect microRNA in low nanomolar concentrations.

The Stevens Group’s latest Nature Materials article entitled "Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate" reports on how cell shape and geometry act as regulators for cell physiology and stem cell signalling. Stevens Group members Thomas von Erlach, Sergio Bertazzo, Christine-Maria Horejs, Stephanie Maynard, Hélène Autefage, Charalampos Kallepitis and Silvia Goldoni contributed with excellent studies along with strong collaborations from the del Río Hernández and Chen research labs. Well done!

The Stevens Group’s paper entitled “Platinum nanocatalyst amplification: Redefining the gold standard for lateral flow immunoassays with ultrabroad dynamic range” reports on an ultrasensitive diagnostic test that outperforms the gold standard point-of-care commercial kit for p24, a biomarker for HIV. This work involved members Colleen Loynachan, Michael Thomas, and Shweta Agarwal and is supported by the EPSRC IRC “i-sense” consortium and our collaborators within “i-sense”.
[Imperial news highlight] [i-sense news highlight]